The literature data, mainly of the last ten years, on the synthesis, reactions, and practical utilisation of seleniumcontaining heterocycles are analysed, treated systematically, and surveyed. The heterocyclic compounds with selenium atom in the ring such as. Seleniumcontaining 5membered heterocycles have emerged as an important class of biological compounds. Photophysical properties and excited state dynamics of 4,7dithien2yl2,1,3benzothiad. Principles and applications cause distortion of the. Therefore, the investigation of new methods for the synthesis of small selenium containing building. Despite the close association of selenium and sulfur chemistry and biology, the synthesis of organoselenium compounds generally and selenium containing heterocycles more specifically, has scarcely been explored compared to their sulfur containing counterparts. Developments in the chemistry of selenaheterocyclic compounds of. In addition, many natural compounds are pharmacologically.
Many of them have important functions in the human organism. However, heterocycles with other heteroatoms, such as phosphorus and selenium, also appear. Synthetic investigation of 3amino2ethylselenopyridine carboxylate using sodium borohydride sh. Seleniumcontaining heterocycles from isoselenocyanates. A large number of original papers concerned with the chemistry, and biology of. Selenium containing heterocycles from isoselenocyanates. Jan epsztajn arkivoc 2007 vi 1446 selenonium salts eg. This may be attributed to the high toxicity and less stability of many selenium reagents. A monte carlo sensitivity analysis of cf 2 and cf radical densities in a cc4f8 plasma. Roughly more than one half of all natural products contains heterocyclic components. Request pdf seleniumcontaining heterocycles the literature data, mainly of. Use of hydrazine for the synthesis of 1,3,4selenadiazine derivatives iii. Biologically significant seleniumcontaining heterocycles biologically significant seleniumcontaining heterocycles ninomiya, masayuki.
Request pdf recent advances in the chemistry of seleniumcontaining. Complications during alkyl and oxyacyl radical generation in the preparation of sulfur. Synthesis, characterization, and spectral and biological. As selenium containing is very important for the organism, various diseases can result from selenium deficiency. Highlights selenium represents an essential element for organisms. The most significant and important result is that the p product is preferred, contrary to what happened for the dihydro5helicene with methyl substituents, and in agreement with experiment. Review biologically significant seleniumcontaining heterocycles. Thiohydroxamic esters derived from 5benzylseleonpentanoic acid, 6benzylselenohexanoic acid and 7benzylselenoheptanoic acid decompose smoothly upon irradiation, with the loss of carbon dioxide, to give tetrahydroselenophene, selenane and selenopane in good yield. This article appeared in a journal published by elsevier. Qm and qmmm studies on organic and inorganic systems. Seleniumcontaining heterocycles using selenoamides, selenoureas, selenazadienes, and isoselenocyanates, heterocycles, 81, 9. These heterocycles have been applied as antioxidants, cytotoxic agents, apoptosis inducers and chemopreventors, and they possess antidepressant activity, among others. Synthesis and reactions of 2amino4,5,6,7tetrahydro1benzoselenophene3carbonitrile with anticipated biological activity.
Therefore, the investigation of new methods for the synthesis of small seleniumcontaining building. Synthesis and reactions of 2amino4,5,6,7 tetrahydro1benzoselenophene3carbonitrile with anticipated biological. Dec 01, 2011 biologically significant selenium containing heterocycles biologically significant selenium containing heterocycles ninomiya, masayuki. Despite the close association of selenium and sulfur chemistry and biology, the synthesis of organoselenium compounds generally and seleniumcontaining heterocycles more specifically, has scarcely been explored compared to their sulfurcontaining counterparts. This compound has a unique chemical structure and is the first example of a natural heterocyclic compound with a selenoketone derived from. The invention provides a method for making a seleniumcarrier conjugate by covalently attaching i an organic selenium compound selected from the group consisting of rseh, rser, rser, rseser and rseser, wherein r and r are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic.
Recent advances in the chemistry of seleniumcontaining. Synthesis of 2,4disubstituted thiazoles and selenazoles. Pdf biologically significant seleniumcontaining heterocycles. Zade department of chemical sciences, indian institute of science education and research iiser kolkata, mohanpur 741252, india. Seleniumcontaining heterocycles 9101112 represent an important family of. References are incorporated into the text using the journal codes adopted by comprehensive heterocyclic chemistry, and are listed in full at the end of each. The selenium containing compound in the tuna blood was purified in several chromatographic steps of c18 reverse phase hplc and gel filtration chromatography. Selenium containing imidazolium salt in designing single. Developments in the chemistry of selenaheterocyclic compounds. On the other hand, the current interest in selenium containing heterocycles is a result of their chemical properties and biological activities.
Heterocyclic annulated pyridazines continue to attract considerable attention, which mainly arises from the large variety of interesting pharmacological activities, herbicides, insecticides and fungicides. The preliminary indications for the successful synthesis of desired compounds iiiviii were the solubility, physical states, and a difference in the melting points mp of benzimidazolium salts and their respective selenium adducts. Thick tellurium target preparation by vacuum deposition. Unexpected leaving ability of phenyltelluroformates in the presence of internal nucleophiles. Advances in bio mimetics self assembly nanotechnology. The syntheses of azolium salts iiiv and respective senhc adducts viviii were carried out according to our previously reported work. As a consequence, selenium containing heterocycles are of considerable biochemical and pharmacological relevance. May, 2015 recent data on the synthesis of various selenoureas and selenium containing heterocycles derived therefrom have been systemized, analyzed, and generalized. The seleniumcontaining compound was purified from the tuna blood.
Ionradical organic chemistry principles and applications. Recent data on the synthesis of various selenoureas and seleniumcontaining heterocycles derived therefrom have been systemized, analyzed, and generalized. Jul 21, 1998 the present invention improves upon the invention set forth in u. Identification of a novel seleniumcontaining compound. Notably, stabilization of the cationradical center prevents a proton from being expelled. Seleniumcontaining heterocycles request pdf researchgate. Selenium represents an essential element for organisms as various diseases can result from selenium deficiency. Method for the preparation of free radical pharmaceuticals.
The most stable tran sition state is itransoid, leading to the p product, and the lowest energy path going to the m product goes through iicisoid, 4. In the past five years, several articles related to the. Highresolution mass spectroscopy using electrospray ionization esi. Synthesis of selenoureas and heterocycles based thereon. Some of selenaheterocyclic systems containing sete, sep, seb, sezn or sesn bonds which. Abdelhafez et al 2006 phosphorus sulfur and silicon and the related elements 181 2297 crossref. Selenium containing imidazolium salt in designing single source precursors for silver bromide and selenide nanoparticles hemant joshi, a kamal nayan sharma, a ved vati singh, a pradhumn singh a and ajai kumar singh a. As selenium containing is very important for the organism, various diseases can result from selenium.
Developments in the chemistry of selenaheterocyclic. The seleniumcontaining compound in the tuna blood was purified in several chromatographic steps of c18 reverse phase hplc and gel filtration chromatography. Foreword this is the seventeenth annual volume of progress in heterocyclic chemistry, which covers the literature published during 2004 on most of the important heterocyclic ring systems. The most frequently occuring heteroatoms in heterocycles are nitrogen, oxygen, and sulfur. Biologically significant seleniumcontaining heterocycles. Advances in bio mimetics free ebook download as pdf file. Selenaheterocyclic compounds, particularly the benzisoselenazol32hones and other cyclic selenenamides, seleninate esters, spirodioxyselenuranes, selenium containing. Recent advances in the synthesis of biologically relevant.
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